Eastern Panama Vacation Packages 2025 from $688

Eastern Panama flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

per person

Aug 16 - Aug 20

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Punta Caracol Acqua Lodge

Punta Caracol

Save 100% on your flight

per person

Jul 10 - Jul 15

found 14 hours ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this lodge. WiFi in public areas is free. A coffee shop, a terrace, and a garden are also on offer.

Hotel Panamonte

per person

Jul 10 - Jul 15

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this hotel. Guests will appreciate free perks like free self parking and WiFi in public areas. You'll appreciate the area shuttle, terrace, and garden.

The Sands by Wynwood House

Calidonia

Save 100% on your flight

per person

Jul 10 - Jul 15

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

An outdoor pool is available at this apartment.

Hotel Plaza Herrera

Casco Viejo

per person

Aug 16 - Aug 20

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A restaurant, valet parking, and a 24-hour front desk are among this hotel's amenities. Guests will appreciate free perks like full breakfast and WiFi in public areas. A coffee shop, luggage storage, and laundry facilities are also on offer.

Top Eastern Panama hotels deals

Private Over the Water Cabin on San Blas Island

9.542876, -78.899058, Narganá, San Blas

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This cabin features a restaurant, a coffee shop, and a terrace. Enjoy the free local cuisine breakfast each morning. A garden and a snack bar/deli are also provided.

Breakfast included

Kitchen

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

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Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attraction Museum of the Kuna Nation is located nearby.

Breakfast included

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

$540 nightly

$594 total

Jun 7 - Jun 8

Total includes taxes and fees

This smoke-free resort features a private beach, a full-service spa, and 2 restaurants. Relax with free beach cabanas, sun loungers, and beach umbrellas. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like full breakfast and free self parking.

On private beach

Pool

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island, Narganá, Guna Yala

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This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Breakfast included

Restaurant

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón

$108 nightly

$119 total

Jul 1 - Jul 2

Total includes taxes and fees

A restaurant and an outdoor pool are featured at this hotel. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A garden and a virtual front desk are also provided.

Pool

Breakfast included

Cabins in Asserya Island - San Blas paradise - meals included

Aroma Island (Isla Anzuelo), Narganá, Guna Yala

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A marina and a restaurant are featured at this hotel. Enjoy the free local cuisine breakfast each morning. You'll appreciate the area shuttle and snack bar/deli.

Breakfast included

Restaurant

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Secluded island in the Guna Yala region of Panama

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as $688. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life’s a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You’ll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.